Joe Dirt is a janitor with a mullet hairdo, acid-washed jeans and a dream to find the parents that he lost at the Grand Canyon when he was a belligerent, trailer park-raised eight-year-old. Now, blasting Van Halen in his jacked-up economy car, the irrepressibly optimistic Joe hits the road alone in search of his folks. As his wandering, misguided search takes him from one hilarious misadventure to another, Joe finds his way to Los Angeles, where a shock-jock brings Joe on his radio show to...

Frank Detomello is a slovenly zoo keeper, and simple father to the only young and bright girl named Shane, who catches a cold right after he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones, works as a member of Immunity cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax...